Small Batch Capping Machine (ASEPTiCell™ VSM-25)

Ready-to-Fill Nested Vial Sealing

Processing pre-sterilized nested vials brings with it challenges that are not easily solved with traditional solutions.  Such is the case with vial sealing or capping.  As a technology leader for processing ready-to-fill nested vials, AST developed the Vial Sealing Module (VSM).  The VSM’s innovative design provides a compact and reliable vial sealing solution that is compliant with global cGMP requirements, including Annex I.

The Vial Sealing Module’s versatile design is the perfect solution to integrate with existing filling lines being converted to process nested vials, as a standalone solution or to be integrated with AST’s GENiSYS or ASEPTiCell systems.

Applications include:

  • Clinical materials manufacturing
  • Small batch commercial manufacturing
  • R&D and process development


  • Capping of nested vials
  • Repeatable and reliable vial closing
  • Gentle container handling
  • Annex I compliant
  • Space saving design
  • Integrates with AST and other OEM filling systems
  • No tray loader required for sealed vials

The Vial Sealing Module (VSM) is a fully automated solution dedicated to closing or capping of nested pre-sterilized nested vials. The vial closing module’s design and robotic vial handling ensures gentle handling of the product and the vial throughout the aseptic capping process.

Closing of the vials is performed with a spinning roller to provide a repeatable high quality seal. The VSM includes several advanced capabilities to control and monitor the most important aspects of the process including; stopper compression force, rotation speed, aluminum cap presence, stopper gap inspection and environmental monitoring.  

The compact and versatile design allows the vial capping module to be used as a standalone system or can be integrated with the ASEPTiCell r25 or i25 filling module to provide a complete and versatile fill—finish solution.

Coming Soon!

Technical Information

Dimensions (LxWxH)

1473mm x 1143mm x 1981mm


Pre-sterilized, nested vials

Vial Sizes:

2mL to 50mL (ISO 2R – 50R)

Cap Sizes:

13mm & 20mm

Production Rate:

Up to 2000 units per hour

Sealing Method

Spinning roller

Barrier Options:

Restricted Access Barrier System (RABS)

Electrical Utilities:

480/220VAC – 60/50Hz.

Compressed Air Utilities:

6 bar @ 1 SCFM

Available Options:

  • Raised stopper inspection
  • Cap applied force monitoring
  • Viable and non-viable environmental monitoring

*Figures are typical.  Actual performance results vary depending upon application requirements.

Coming Soon!


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