Syringe & Cartridge Closing Machine

Vacuum Syringe Sealing For Small Batch Processing

AST’s Syringe & Cartridge Closing Machine is a versatile system that provides complete and accurate control of the syringe and cartridge closing process.  The system’s innovative design uses AST’s patented multi-stage vacuum insertion process uses vacuum with a servo controlled mechanical assist to precisely position the piston into the syringe or cartridge under optimized conditions every time.

The operator interacts with an intuitive, high resolution touchscreen interface to create unique recipes, monitor the process and control the machine.  The system monitors and records critical process parameters in the system database that can be used to create a batch report upon completion of the batch.  This information can also be exported and viewed within Excel for batch analysis and process optimization.

The system can be quickly and easily changed to close any commercially available glass or plastic pre-filled syringe or cartridge.  The container closing flexibility makes the closing machine and ideal tool for any small batch processing application for pre-filled syringes or cartridges.

Applications include:

  • R&D and process development
  • Clinical trial materials manufacturing
  • Personalized medicine
  • Compounding pharmacies
  • Stability studies


  • Automated syringe and cartridge piston placement
  • Simple format change-over
  • Fully controlled and monitored piston insertion
  • Historical process data accessible with Excel
  • Intuitive machine interface
  • Compact system footprint allows for placement with an isolator, biological safety cabinet or LAF

AST’s syringe and cartridge closing machine is a versatile system for automated piston insertion into pre-filled syringes and cartridges.  The system is ideal for semi-automatic processing of small batch production in the laboratory or cGMP settings.  The system’s flexibility allows processing of glass and plastic syringes ranging from 0.5mL to 20mL with the ability to handle a variety of piston combinations. 

The pre-filled syringes or cartridges and the pistons are manually placed on the machine by the operator.  Once the syringes or cartridges are positioned the closing machine utilizes AST’s patented multi-stage vacuum insertion process to evacuate the syringe or cartridge then gently places the piston into its final desired depth using an electronically controlled insertion rod.

An advanced motion control system allows operators to conveniently carry out all parameter adjustments directly at the touchscreen interface.  In addition to providing intuitive operation and recipe management, the control system can create batch reports that can be printed or stored directly to the user’s information system.

The aseptic and compact design of the machine makes it well suited for cGMP environments and can be placed within isolators, biological safety cabinets or laminar air flow (LAF) hoods.  The system is completely compatible isolator bio-decontamination using hydrogen peroxide, and can be manually cleaned using common reagents like isopropyl alcohol and sporicides.

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Technical Information

Dimensions (LxWxH)

508mm x 559mm x 559mm


Syringes & Pre-Capped Cartridges

Syringe Sizes:

0.5mL to 20mL

Production Rate:

Up to 480 units per hour

Insertion Method:

Vacuum with mechanical assist


20 kg (45 lbs.)

Air Utilities:

6 bar (90 PSI) clean dry air

Electrical Utilities:

110/220VAC – 60/50Hz.


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