Bench-Top Vial Sealing Machine

The vials or bottles are manually placed on the machine by the operator. Once placed, the sealing process is initiated, and the sealing head moves down to compress the vial stopper until the closed-loop compression force feedback confirms the operator programmed compression setting is achieved. With the stopper compressed the vial is rotated and the free-spinning disk gently forms the aluminum skirt of the cap around the neck of the vial. This sealing process maintains the compression of the rubber stopper, generates fewer particles and provides a pharmaceutically aesthetic seal without the witness marks common to jaw style crimpers.

• ASTView high-resolution interface provides intelligent and intuitive control of the system for creating unique recipes and real-time process monitoring
• Dispense system provides accurate and repeatable container filling with automatic volumetric monitoring and adjustment
• Uniform vial sealing using a sealing disk provides a repeatable quality overseal that eliminates the common challenges of jaw style crimping
• Electronic Batch Report (EBR) System records critical process information that can be used to create a 21 CFR Part 11 compliant batch report to simplify the technology transfer or regulatory filing processes
• Compact design makes the system ideally suited for aseptic isolators, biological safety cabinets or laminar airflow hood

AST’s Vial Sealing System (VSS) is a benchtop, semi-automatic machine used for sealing or capping of pharmaceutical vials and bottles with aluminum caps. The system is designed to meet the demanding requirements for small batch processing of sterile pharmaceutical and biotechnology applications. The Vial Sealing Systems’ versatility provides the ability to process a wide range of vial and cap types and sizes.

• R&D, preclinical and process development
• Clinical trial materials manufacturing
• Gene & cell therapies
• Small batch commercial drug products
• Stability studies
• Compounding pharmacies