Pharmaceutical Technology on AST’s Latest Aseptic Fill-Finish Solution
Josh Russell, AST Vice President of Sales & Marketing, sat down with Pharmaceutical Technology at Interphex 2024 to discuss recent developments and advancements at AST, including an American-made isolator solution, an innovative new decontamination technology, and the benefits of AST’s comprehensive, integrated turnkey approach. Highlights and Themes: Modular technology: AST’s innovative approach to aseptic fill-finish […]
Isolator Air Handling: Advancements and Considerations for Fill-Finish Processing
In the fill-finish manufacturing of parenteral liquid pharmaceuticals, maintaining product sterility is paramount. The choice of what kind of barrier technology to utilize becomes key, as operations must account for the production environment and the level of control and efficiency needed to hit key production milestones. For an increasing amount of industry professionals, isolators are […]
The Quest for Sterility Assurance: A New Approach to Isolator Decontamination
One of the more challenging, essential aspects of planning for an isolated fill-finish operation is determining the approach to decontamination. Sterility assurance is a top priority, and ensuring a selected method meets regulatory thresholds is vital.
The Next-Generation Isolator: A User-Friendly Solution for Fill-Finish Professionals
When AST came to the table on the design for our new fill-finish isolator, one of the first areas AST engineers wanted to address was the usability and accessibility of the isolator and corresponding operations. With our customers’ point of view in mind, we wanted to address specific points of friction routinely encountered by operators […]
AST Perspectives: Reimagining Fill-Finish Isolator Design
By Steven Ng, CTO & VP of Customer Service This past October, AST announced a groundbreaking collaboration with Germfree on a new fill-finish isolator. This exciting announcement was the result of just over a year of brainstorming, research, and development, as our team at AST set out to create an isolator solution that would meet […]
Toolless Change Parts: A Flexible Solution
Aseptic fill-finish professionals are continually looking to augment their approach to a market that continues to grow and reflect innovations happening around sterile parenteral treatments. When considering the flexibility of an operation, it’s important to investigate every aspect of the fill-finish process. Flexibility applies to any process or technical optimization that quickens scalability and removes […]
AST Perspectives: Looking Towards a Fill-Finish Future Rooted in American Ingenuity
A Word from AST President & CEO Joe Hoff It’s common practice at AST to revisit our Mission Statement as we go about our work to provide quality fill-finish solutions to our customers. That mission—to enhance the reliability, productivity and safety of aseptic processing by offering intelligent, intuitive, and innovative solutions—informs every aspect of what […]
Ready and Sealed: The RTU Advantage for Optimal Vial Sealing
For small-batch, high-value drug products, the aseptic advantages of pre-sterilized ready-to-use vials are clear. To realize the full scope of benefits that RTU vials can provide, integration with traditional processes and equipment must be carefully considered. Modern and flexible technologies such as robotics are key to seamlessly integrating RTU vials into aseptic fill/finish processes. The […]
Technology Transfer Strategies: Fill-Finish Automation and Robotics
Throughout the lifecycle of a drug product, many critical target points for optimization make all the difference in the time-to-market equation. A holistic approach to the drug development process that’s able to anticipate challenges in production, regulatory requirements, and manufacturing practices should be considered. A key component of this approach is establishing early and clear […]
Preparing for the Small Batch Revolution: Identifying Successful Biopharmaceutical Partnerships
Small-batch manufacturing of liquid pharmaceuticals is slated for exponential growth in the coming years and represents exciting possibilities for the future of medicine and personalized healthcare. Whether biologics, biosimilars, or orphan drugs developed in the fight against rare diseases, technology is providing solutions for the manufacturing challenges traditionally associated with small-batch aseptic processing and consequently […]